Email this article Molecular Basis of Cardioprotection in Ischemic Heart Disease
- Authors: Shemarova I.V.1, Nesterov V.P.1
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Affiliations:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Issue: Vol 55, No 3 (2019)
- Pages: 163-173
- Section: Reviews
- URL: https://journals.rcsi.science/0022-0930/article/view/159721
- DOI: https://doi.org/10.1134/S0022093019030013
- ID: 159721
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Abstract
The review addresses the mechanisms of adaptation of cardiomyocytes to hypoxia and ischemia and analyzes the signaling mechanisms responsible for expression of metabolic genes and the formation of tolerance to hypoxia and ischemia with a special focus on the role of HIF-1α, succinate, and ATP-dependent K+-channels (KATP-channels) in the regulation of adaptive responses of cardiomyocytes during myocardial ischemia.
Keywords
About the authors
I. V. Shemarova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Author for correspondence.
Email: irina-shemarova@yandex.ru
Russian Federation, St. Petersburg
V. P. Nesterov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: irina-shemarova@yandex.ru
Russian Federation, St. Petersburg
