Genetic Factors of Reflex Epilepsies

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Abstract

Reflex epilepsy is a relatively rare form of epilepsy, occurring only in five percent of all cases of this disease. The genetic factors of reflex epilepsy are diverse and, in general, poorly studied. This review examines the main results obtained in recent years in the study of molecular genetic factors of reflex epilepsy, including new data on the mechanisms of genetic regulation in reflex epilepsy caused by triggers such as audio and video stimulation, food consumption, reading, contact with water and hypoxia. The results obtained in studies on animal models and patients using next-generation sequencing technology are presented.

About the authors

N. A. Dudko

Center for Genetics and Life Science, “Sirius” University of Science and Technology; Vavilov Institute of General Genetics, Russian Academy of Sciences

Author for correspondence.
Email: dudko@rogaevlab.ru
Russia, 354340, Krasnodar region, pgt. Sirius; Russia, 119991, Moscow

S. S. Kunizheva

Center for Genetics and Life Science, “Sirius” University of Science and Technology; Vavilov Institute of General Genetics, Russian Academy of Sciences; Center for Genetics and Genetic Technologies, Lomonosov Moscow State University

Email: dudko@rogaevlab.ru
Russia, 354340, Krasnodar region, pgt. Sirius; Russia, 119991, Moscow; Russia, 119234, Moscow

T. V. Andreeva

Center for Genetics and Life Science, “Sirius” University of Science and Technology; Vavilov Institute of General Genetics, Russian Academy of Sciences; Center for Genetics and Genetic Technologies, Lomonosov Moscow State University

Email: dudko@rogaevlab.ru
Russia, 354340, Krasnodar region, pgt. Sirius; Russia, 119991, Moscow; Russia, 119234, Moscow

I. Yu. Adrianova

Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: dudko@rogaevlab.ru
Russia, 119991, Moscow

E. I. Rogaev

Center for Genetics and Life Science, “Sirius” University of Science and Technology; Center for Genetics and Genetic Technologies, Lomonosov Moscow State University; Department of Psychiatry, UMass Chan Medical School

Email: dudko@rogaevlab.ru
Russia, 354340, Krasnodar region, pgt. Sirius; Russia, 119234, Moscow; USA, 01545, MA, Worcester

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