The CRP Gene’s Role in the Relations between Childhood Adversity and History of Suicide Attempts in Schizophrenia

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Abstract

Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of birth on the development of the disease. This study aimed to explore whether the CRP gene also moderates the relations between childhood adversity and clinical characteristics of schizophrenia. The relations between childhood adversity, genotypes at rs2794521within the CRP locus, syndromes measured as five factors and two negative subfactors of the Positive and Negative Syndrome Scale, and history of suicide attempts were analyzed in 921 schizophrenia patients using analyses of covariances, Pearson’s chi-squared test, and logistic regression. A significant effect of genotype on suicide attempts in patients exposed to childhood adversity was found. The result suggests a moderating role of genetic determinants of inflammation in translating early life psychological stress effects into risk of suicide attempts in schizophrenia.

About the authors

M. V. Alfimova

Mental Health Research Center

Author for correspondence.
Email: m.alfimova@gmail.com
Russia, 115522, Moscow

T. V. Lezheiko

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

M. V. Gabaeva

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

V. V. Plakunova

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

V. A. Mikhailova

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

V. G. Kaleda

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

V. E. Golimbet

Mental Health Research Center

Email: m.alfimova@gmail.com
Russia, 115522, Moscow

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Copyright (c) 2023 М.В. Алфимова, Т.В. Лежейко, М.В. Габаева, В.В. Плакунова, В.А. Михайлова, В.Г. Каледа, В.Е. Голимбет

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