The CRP Gene’s Role in the Relations between Childhood Adversity and History of Suicide Attempts in Schizophrenia
- 作者: Alfimova M.1, Lezheiko T.1, Gabaeva M.1, Plakunova V.1, Mikhailova V.1, Kaleda V.1, Golimbet V.1
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隶属关系:
- Mental Health Research Center
- 期: 卷 59, 编号 2 (2023)
- 页面: 238-243
- 栏目: КРАТКИЕ СООБЩЕНИЯ
- URL: https://journals.rcsi.science/0016-6758/article/view/134561
- DOI: https://doi.org/10.31857/S0016675823020029
- EDN: https://elibrary.ru/KWXQKF
- ID: 134561
如何引用文章
详细
Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of birth on the development of the disease. This study aimed to explore whether the CRP gene also moderates the relations between childhood adversity and clinical characteristics of schizophrenia. The relations between childhood adversity, genotypes at rs2794521within the CRP locus, syndromes measured as five factors and two negative subfactors of the Positive and Negative Syndrome Scale, and history of suicide attempts were analyzed in 921 schizophrenia patients using analyses of covariances, Pearson’s chi-squared test, and logistic regression. A significant effect of genotype on suicide attempts in patients exposed to childhood adversity was found. The result suggests a moderating role of genetic determinants of inflammation in translating early life psychological stress effects into risk of suicide attempts in schizophrenia.
作者简介
M. Alfimova
Mental Health Research Center
编辑信件的主要联系方式.
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
T. Lezheiko
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
M. Gabaeva
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
V. Plakunova
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
V. Mikhailova
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
V. Kaleda
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
V. Golimbet
Mental Health Research Center
Email: m.alfimova@gmail.com
Russia, 115522, Moscow
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