Cationic Copolymerization of Cholesterol Vinyl Ether with N-Allenylpyrrolidone: A Route to Pharmacologically Promising Oligomers
- Authors: Markova M.V.1, Tatarinova I.V.1, Tarasova O.A.1, Apartsin K.A.2, Kireeva V.V.2, Trofimov B.A.1
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Affiliations:
- Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
- Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 485, No 2 (2019)
- Pages: 112-115
- Section: Chemistry
- URL: https://journals.rcsi.science/0012-5008/article/view/154418
- DOI: https://doi.org/10.1134/S0012500819040037
- ID: 154418
Cite item
Abstract
Cationic copolymerization of cholesterol vinyl ether with N-allenylpyrrolidone yielded co-oligomers with molecular mass of 1200–2100. The polymerization of N-allenylpyrrolidone involves both 1,2- and 2,3-positions of the allenyl substituent to give four types of units as a result of prototropic isomerization of the initially formed structures. In the developed method, the composition of co-oligomers can be controlled and, hence, their hydrophilic/hydrophobic balance, solubility, and membranotropic properties can also be contolled to change the potential biological activity of the products.
About the authors
M. V. Markova
Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033
I. V. Tatarinova
Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033
O. A. Tarasova
Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033
K. A. Apartsin
Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033
V. V. Kireeva
Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033
B. A. Trofimov
Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Author for correspondence.
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk, 664033