Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines


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We studied the effect of the organoselenium compound 2,6-dipyridinium-9-selenium-bicyclo[ 3,3,1]nonan dibromide (974zh) on the severity of pathological changes in the organs of experimental animals immunized with live tularemia and brucellosis vaccines. It was found that 974zh reduced reactogenicity of vaccines for experimental animals. Our findings indicate the prospects for further studies of the effects of 974zh on the functional state of experimental animals.

作者简介

O. Yurieva

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

V. Dubrovina

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

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Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

V. Potapov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

M. Musalov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

T. Starovoitova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

T. Ivanova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

A. Gromova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

T. Shkaruba

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

S. Balakhonov

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk


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