Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines


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Аннотация

We studied the effect of the organoselenium compound 2,6-dipyridinium-9-selenium-bicyclo[ 3,3,1]nonan dibromide (974zh) on the severity of pathological changes in the organs of experimental animals immunized with live tularemia and brucellosis vaccines. It was found that 974zh reduced reactogenicity of vaccines for experimental animals. Our findings indicate the prospects for further studies of the effects of 974zh on the functional state of experimental animals.

Об авторах

O. Yurieva

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

V. Dubrovina

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Автор, ответственный за переписку.
Email: dubrovina-valya@mail.ru
Россия, Irkutsk

V. Potapov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

M. Musalov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Science

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

T. Starovoitova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

T. Ivanova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

A. Gromova

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

T. Shkaruba

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk

S. Balakhonov

Irkutsk Research Anti-Plague Institute, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: dubrovina-valya@mail.ru
Россия, Irkutsk


© Springer Science+Business Media, LLC, part of Springer Nature, 2019

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