VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway
- 作者: Spirina L.1,2, Kondakova I.1, Yurmazov Z.1, Usynin E.1, Slonimskaya E.1,2, Lushnikova N.1, Podnebesnova D.2
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隶属关系:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Siberian State Medical University
- 期: 卷 167, 编号 5 (2019)
- 页面: 671-675
- 栏目: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242011
- DOI: https://doi.org/10.1007/s10517-019-04596-9
- ID: 242011
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详细
Von Hippel—Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.
作者简介
L. Spirina
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
编辑信件的主要联系方式.
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk; Tomsk
I. Kondakova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
Z. Yurmazov
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
E. Usynin
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
E. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk; Tomsk
N. Lushnikova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
D. Podnebesnova
Siberian State Medical University
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk