VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway
- Autores: Spirina L.1,2, Kondakova I.1, Yurmazov Z.1, Usynin E.1, Slonimskaya E.1,2, Lushnikova N.1, Podnebesnova D.2
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Afiliações:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Siberian State Medical University
- Edição: Volume 167, Nº 5 (2019)
- Páginas: 671-675
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242011
- DOI: https://doi.org/10.1007/s10517-019-04596-9
- ID: 242011
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Resumo
Von Hippel—Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.
Sobre autores
L. Spirina
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Autor responsável pela correspondência
Email: spirinalvl@mail.ru
Rússia, Tomsk; Tomsk
I. Kondakova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Rússia, Tomsk
Z. Yurmazov
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Rússia, Tomsk
E. Usynin
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Rússia, Tomsk
E. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Email: spirinalvl@mail.ru
Rússia, Tomsk; Tomsk
N. Lushnikova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Rússia, Tomsk
D. Podnebesnova
Siberian State Medical University
Email: spirinalvl@mail.ru
Rússia, Tomsk
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