VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway
- Авторлар: Spirina L.1,2, Kondakova I.1, Yurmazov Z.1, Usynin E.1, Slonimskaya E.1,2, Lushnikova N.1, Podnebesnova D.2
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Мекемелер:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Siberian State Medical University
- Шығарылым: Том 167, № 5 (2019)
- Беттер: 671-675
- Бөлім: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242011
- DOI: https://doi.org/10.1007/s10517-019-04596-9
- ID: 242011
Дәйексөз келтіру
Аннотация
Von Hippel—Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.
Авторлар туралы
L. Spirina
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Хат алмасуға жауапты Автор.
Email: spirinalvl@mail.ru
Ресей, Tomsk; Tomsk
I. Kondakova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Ресей, Tomsk
Z. Yurmazov
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Ресей, Tomsk
E. Usynin
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Ресей, Tomsk
E. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Email: spirinalvl@mail.ru
Ресей, Tomsk; Tomsk
N. Lushnikova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Ресей, Tomsk
D. Podnebesnova
Siberian State Medical University
Email: spirinalvl@mail.ru
Ресей, Tomsk