VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway
- Authors: Spirina L.V.1,2, Kondakova I.V.1, Yurmazov Z.A.1, Usynin E.A.1, Slonimskaya E.M.1,2, Lushnikova N.A.1, Podnebesnova D.V.2
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Affiliations:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Siberian State Medical University
- Issue: Vol 167, No 5 (2019)
- Pages: 671-675
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242011
- DOI: https://doi.org/10.1007/s10517-019-04596-9
- ID: 242011
Cite item
Abstract
Von Hippel—Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.
About the authors
L. V. Spirina
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Author for correspondence.
Email: spirinalvl@mail.ru
Russian Federation, Tomsk; Tomsk
I. V. Kondakova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
Z. A. Yurmazov
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
E. A. Usynin
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
E. M. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Email: spirinalvl@mail.ru
Russian Federation, Tomsk; Tomsk
N. A. Lushnikova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
D. V. Podnebesnova
Siberian State Medical University
Email: spirinalvl@mail.ru
Russian Federation, Tomsk