Experimental Study of Flakozid Activity in Viral Hepatitis C In Vitro
- 作者: Fateeva T.1, Deryabin P.2, Bortnikova V.1, Krepkova L.1, Mizina P.1
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隶属关系:
- Institute of Medicinal and Aromatic Plants
- D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
- 期: 卷 167, 编号 4 (2019)
- 页面: 479-481
- 栏目: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/241811
- DOI: https://doi.org/10.1007/s10517-019-04554-5
- ID: 241811
如何引用文章
详细
Antiviral activity of a Russian drug flakozid towards infection caused by a cytopathogenic variant of hepatitis C virus in SPEV cells is studied. Flakozid is an individual natural flavonoid glycoside 7-O-β-D-glucopyranoside-8-(methyl-but)-2-enyl)-5,4’-dioxyflavanolol), isolated from the leaves of Phellodendron amurense Rupr. and Ph. amurense var. lavallei (Dode) Sprague, Rutaceae family. High antiviral activity of flakozid manifests in response to its addition into the monolayer of SPEV cells infected by hepatitis C virus during all periods of experiment. Flakozid exhibits weak cytotoxicity and no viricidal activity towards hepatitis C virus, which is comparable to activity of ribavirin (antiviral drug). Chemotherapeutic index of flakozid is 15-25 times higher than that of the reference drug ribavirin.
作者简介
T. Fateeva
Institute of Medicinal and Aromatic Plants
编辑信件的主要联系方式.
Email: fateeva2151@mail.ru
俄罗斯联邦, Moscow
P. Deryabin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
Email: fateeva2151@mail.ru
俄罗斯联邦, Moscow
V. Bortnikova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
俄罗斯联邦, Moscow
L. Krepkova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
俄罗斯联邦, Moscow
P. Mizina
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
俄罗斯联邦, Moscow
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