Experimental Study of Flakozid Activity in Viral Hepatitis C In Vitro
- Authors: Fateeva T.V.1, Deryabin P.G.2, Bortnikova V.V.1, Krepkova L.V.1, Mizina P.G.1
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Affiliations:
- Institute of Medicinal and Aromatic Plants
- D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
- Issue: Vol 167, No 4 (2019)
- Pages: 479-481
- Section: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/241811
- DOI: https://doi.org/10.1007/s10517-019-04554-5
- ID: 241811
Cite item
Abstract
Antiviral activity of a Russian drug flakozid towards infection caused by a cytopathogenic variant of hepatitis C virus in SPEV cells is studied. Flakozid is an individual natural flavonoid glycoside 7-O-β-D-glucopyranoside-8-(methyl-but)-2-enyl)-5,4’-dioxyflavanolol), isolated from the leaves of Phellodendron amurense Rupr. and Ph. amurense var. lavallei (Dode) Sprague, Rutaceae family. High antiviral activity of flakozid manifests in response to its addition into the monolayer of SPEV cells infected by hepatitis C virus during all periods of experiment. Flakozid exhibits weak cytotoxicity and no viricidal activity towards hepatitis C virus, which is comparable to activity of ribavirin (antiviral drug). Chemotherapeutic index of flakozid is 15-25 times higher than that of the reference drug ribavirin.
About the authors
T. V. Fateeva
Institute of Medicinal and Aromatic Plants
Author for correspondence.
Email: fateeva2151@mail.ru
Russian Federation, Moscow
P. G. Deryabin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
Email: fateeva2151@mail.ru
Russian Federation, Moscow
V. V. Bortnikova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Russian Federation, Moscow
L. V. Krepkova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Russian Federation, Moscow
P. G. Mizina
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Russian Federation, Moscow