Experimental Study of Flakozid Activity in Viral Hepatitis C In Vitro
- Авторлар: Fateeva T.1, Deryabin P.2, Bortnikova V.1, Krepkova L.1, Mizina P.1
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Мекемелер:
- Institute of Medicinal and Aromatic Plants
- D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
- Шығарылым: Том 167, № 4 (2019)
- Беттер: 479-481
- Бөлім: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/241811
- DOI: https://doi.org/10.1007/s10517-019-04554-5
- ID: 241811
Дәйексөз келтіру
Аннотация
Antiviral activity of a Russian drug flakozid towards infection caused by a cytopathogenic variant of hepatitis C virus in SPEV cells is studied. Flakozid is an individual natural flavonoid glycoside 7-O-β-D-glucopyranoside-8-(methyl-but)-2-enyl)-5,4’-dioxyflavanolol), isolated from the leaves of Phellodendron amurense Rupr. and Ph. amurense var. lavallei (Dode) Sprague, Rutaceae family. High antiviral activity of flakozid manifests in response to its addition into the monolayer of SPEV cells infected by hepatitis C virus during all periods of experiment. Flakozid exhibits weak cytotoxicity and no viricidal activity towards hepatitis C virus, which is comparable to activity of ribavirin (antiviral drug). Chemotherapeutic index of flakozid is 15-25 times higher than that of the reference drug ribavirin.
Авторлар туралы
T. Fateeva
Institute of Medicinal and Aromatic Plants
Хат алмасуға жауапты Автор.
Email: fateeva2151@mail.ru
Ресей, Moscow
P. Deryabin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of Russia
Email: fateeva2151@mail.ru
Ресей, Moscow
V. Bortnikova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Ресей, Moscow
L. Krepkova
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Ресей, Moscow
P. Mizina
Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
Ресей, Moscow