Cerebral Blood Flow in SHR Rats after Transplantation of Mesenchymal Stem Cells
- 作者: Sokolova I.1, Lobov G.1
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隶属关系:
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- 期: 卷 166, 编号 4 (2019)
- 页面: 586-590
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241211
- DOI: https://doi.org/10.1007/s10517-019-04396-1
- ID: 241211
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详细
Intracerebral transplantation of mesenchymal stem cells to 6- and 12-month-old SHR rats induced angiogenesis in the pia mater. In 6-months-old SHR rats, perfusion in the brain tissue after cell transplantation considerably increased, while in 12-month-old rats it remained practically unchanged. We also observed marked activation of regulatory processes in the cerebral vascular system, most pronounced in 12-month-old rats. Neurogenic and myogenic tone of cerebral vessels increased significantly, while endothelium-dependent tone slightly decreased. The increase in neurogenic and myogenic tone of blood vessels in SHR rats at the age of 6 and 12 months after transplantation of stem cells can be explained by the formation of new smooth muscle cells in the pre-existing arteries walls. Greater muscle mass developed stronger force and contributed to narrowing of the arterial lumen, as a result, there was no increase in blood flow despite the downstream angiogenesis. A slight decrease in endothelium-dependent tone can be explained by increased production of vasodilators by newly formed endothelial cells.
作者简介
I. Sokolova
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: lobovgi@infran.ru
俄罗斯联邦, St. Petersburg
G. Lobov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: lobovgi@infran.ru
俄罗斯联邦, St. Petersburg