Cerebral Blood Flow in SHR Rats after Transplantation of Mesenchymal Stem Cells
- Authors: Sokolova I.B.1, Lobov G.I.1
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Affiliations:
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 166, No 4 (2019)
- Pages: 586-590
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241211
- DOI: https://doi.org/10.1007/s10517-019-04396-1
- ID: 241211
Cite item
Abstract
Intracerebral transplantation of mesenchymal stem cells to 6- and 12-month-old SHR rats induced angiogenesis in the pia mater. In 6-months-old SHR rats, perfusion in the brain tissue after cell transplantation considerably increased, while in 12-month-old rats it remained practically unchanged. We also observed marked activation of regulatory processes in the cerebral vascular system, most pronounced in 12-month-old rats. Neurogenic and myogenic tone of cerebral vessels increased significantly, while endothelium-dependent tone slightly decreased. The increase in neurogenic and myogenic tone of blood vessels in SHR rats at the age of 6 and 12 months after transplantation of stem cells can be explained by the formation of new smooth muscle cells in the pre-existing arteries walls. Greater muscle mass developed stronger force and contributed to narrowing of the arterial lumen, as a result, there was no increase in blood flow despite the downstream angiogenesis. A slight decrease in endothelium-dependent tone can be explained by increased production of vasodilators by newly formed endothelial cells.
About the authors
I. B. Sokolova
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: lobovgi@infran.ru
Russian Federation, St. Petersburg
G. I. Lobov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: lobovgi@infran.ru
Russian Federation, St. Petersburg