Neuroprotective Activity of D-HES in Transient Global Cerebral Ischemia in Rats
- 作者: Anishchenko A.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Kuchin A.2, Chukicheva I.2, Torlopov M.2, Plotnikov M.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- 期: 卷 165, 编号 6 (2018)
- 页面: 728-730
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240711
- DOI: https://doi.org/10.1007/s10517-018-4252-1
- ID: 240711
如何引用文章
详细
We studied the effect of O-((((4-hydroxy-3,5-di(1,7,7-trimethylbicyclo[2.2.1]hept-exo-2-yl) benzyl)oxy)ethyl)-O-(2-hydroxyethyl)-(1→4)-α-D-glucan (D-HES, 80 mg/kg, intravenously) and reference preparation ethylmethylhydroxypyridine succinate (EMHP-S, 50 mg/kg, intravenously) on rat survival and neurological deficit in 24 h after transient global cerebral ischemia in Wistar rats. Intravenous administration of D-HES and EMHP-S significantly increased the number of survivors by 68 and 78%, respectively, in comparison with the control group. In groups treated with D-HES and EMHP-S, the number of animals with severe neurological deficit was significantly lower and the number of animals moderate or mild neurological deficit was significantly higher than in the control group.
作者简介
A. Anishchenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
O. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Shamanaev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
俄罗斯联邦, Syktyvkar
I. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
俄罗斯联邦, Syktyvkar
M. Torlopov
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
俄罗斯联邦, Syktyvkar
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
编辑信件的主要联系方式.
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
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