Neuroprotective Activity of D-HES in Transient Global Cerebral Ischemia in Rats
- Authors: Anishchenko A.M.1, Aliev O.I.1, Sidekhmenova A.V.1, Shamanaev A.Y.1, Kuchin A.V.2, Chukicheva I.Y.2, Torlopov M.A.2, Plotnikov M.B.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Issue: Vol 165, No 6 (2018)
- Pages: 728-730
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240711
- DOI: https://doi.org/10.1007/s10517-018-4252-1
- ID: 240711
Cite item
Abstract
We studied the effect of O-((((4-hydroxy-3,5-di(1,7,7-trimethylbicyclo[2.2.1]hept-exo-2-yl) benzyl)oxy)ethyl)-O-(2-hydroxyethyl)-(1→4)-α-D-glucan (D-HES, 80 mg/kg, intravenously) and reference preparation ethylmethylhydroxypyridine succinate (EMHP-S, 50 mg/kg, intravenously) on rat survival and neurological deficit in 24 h after transient global cerebral ischemia in Wistar rats. Intravenous administration of D-HES and EMHP-S significantly increased the number of survivors by 68 and 78%, respectively, in comparison with the control group. In groups treated with D-HES and EMHP-S, the number of animals with severe neurological deficit was significantly lower and the number of animals moderate or mild neurological deficit was significantly higher than in the control group.
About the authors
A. M. Anishchenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Russian Federation, Tomsk
O. I. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. V. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. Yu. Shamanaev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. V. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Syktyvkar
I. Yu. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Syktyvkar
M. A. Torlopov
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Syktyvkar
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Author for correspondence.
Email: mbp2001@mail.ru
Russian Federation, Tomsk