Neuroprotective Activity of D-HES in Transient Global Cerebral Ischemia in Rats
- Autores: Anishchenko A.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Kuchin A.2, Chukicheva I.2, Torlopov M.2, Plotnikov M.1
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Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Edição: Volume 165, Nº 6 (2018)
- Páginas: 728-730
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240711
- DOI: https://doi.org/10.1007/s10517-018-4252-1
- ID: 240711
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Resumo
We studied the effect of O-((((4-hydroxy-3,5-di(1,7,7-trimethylbicyclo[2.2.1]hept-exo-2-yl) benzyl)oxy)ethyl)-O-(2-hydroxyethyl)-(1→4)-α-D-glucan (D-HES, 80 mg/kg, intravenously) and reference preparation ethylmethylhydroxypyridine succinate (EMHP-S, 50 mg/kg, intravenously) on rat survival and neurological deficit in 24 h after transient global cerebral ischemia in Wistar rats. Intravenous administration of D-HES and EMHP-S significantly increased the number of survivors by 68 and 78%, respectively, in comparison with the control group. In groups treated with D-HES and EMHP-S, the number of animals with severe neurological deficit was significantly lower and the number of animals moderate or mild neurological deficit was significantly higher than in the control group.
Sobre autores
A. Anishchenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Rússia, Tomsk
O. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Shamanaev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Syktyvkar
I. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Syktyvkar
M. Torlopov
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, Syktyvkar
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Autor responsável pela correspondência
Email: mbp2001@mail.ru
Rússia, Tomsk