Neuroprotective Activity of D-HES in Transient Global Cerebral Ischemia in Rats
- Авторы: Anishchenko A.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Kuchin A.2, Chukicheva I.2, Torlopov M.2, Plotnikov M.1
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Учреждения:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Выпуск: Том 165, № 6 (2018)
- Страницы: 728-730
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240711
- DOI: https://doi.org/10.1007/s10517-018-4252-1
- ID: 240711
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Аннотация
We studied the effect of O-((((4-hydroxy-3,5-di(1,7,7-trimethylbicyclo[2.2.1]hept-exo-2-yl) benzyl)oxy)ethyl)-O-(2-hydroxyethyl)-(1→4)-α-D-glucan (D-HES, 80 mg/kg, intravenously) and reference preparation ethylmethylhydroxypyridine succinate (EMHP-S, 50 mg/kg, intravenously) on rat survival and neurological deficit in 24 h after transient global cerebral ischemia in Wistar rats. Intravenous administration of D-HES and EMHP-S significantly increased the number of survivors by 68 and 78%, respectively, in comparison with the control group. In groups treated with D-HES and EMHP-S, the number of animals with severe neurological deficit was significantly lower and the number of animals moderate or mild neurological deficit was significantly higher than in the control group.
Об авторах
A. Anishchenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Россия, Tomsk
O. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Россия, Tomsk
A. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Россия, Tomsk
A. Shamanaev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Email: mbp2001@mail.ru
Россия, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Россия, Syktyvkar
I. Chukicheva
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Россия, Syktyvkar
M. Torlopov
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Россия, Syktyvkar
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre
Автор, ответственный за переписку.
Email: mbp2001@mail.ru
Россия, Tomsk
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