Cardioprotective Activity of 2,6-Diisobornyl-4-Methylphenol in Acute Myocardial Ischemia/Reperfusion in Rats
- 作者: Plotnikova T.1, Chernysheva G.2, Smol’yakova V.2, Shchetinin P.3, Kuchin A.4, Chukicheva I.3, Plotnikov M.2
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隶属关系:
- Siberian State Medical University, Ministry of Health of Russia
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- National Research Tomsk State University
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- 期: 卷 165, 编号 5 (2018)
- 页面: 657-659
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240638
- DOI: https://doi.org/10.1007/s10517-018-4235-2
- ID: 240638
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详细
We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group.
作者简介
T. Plotnikova
Siberian State Medical University, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: plot160@mail.ru
俄罗斯联邦, Tomsk
G. Chernysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
俄罗斯联邦, Tomsk
V. Smol’yakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
俄罗斯联邦, Tomsk
P. Shchetinin
National Research Tomsk State University
Email: plot160@mail.ru
俄罗斯联邦, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: plot160@mail.ru
俄罗斯联邦, Syktyvkar, Komi Republic
I. Chukicheva
National Research Tomsk State University
Email: plot160@mail.ru
俄罗斯联邦, Tomsk
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
俄罗斯联邦, Tomsk