Cardioprotective Activity of 2,6-Diisobornyl-4-Methylphenol in Acute Myocardial Ischemia/Reperfusion in Rats
- Авторы: Plotnikova T.1, Chernysheva G.2, Smol’yakova V.2, Shchetinin P.3, Kuchin A.4, Chukicheva I.3, Plotnikov M.2
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Учреждения:
- Siberian State Medical University, Ministry of Health of Russia
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- National Research Tomsk State University
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Выпуск: Том 165, № 5 (2018)
- Страницы: 657-659
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240638
- DOI: https://doi.org/10.1007/s10517-018-4235-2
- ID: 240638
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Аннотация
We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group.
Об авторах
T. Plotnikova
Siberian State Medical University, Ministry of Health of Russia
Автор, ответственный за переписку.
Email: plot160@mail.ru
Россия, Tomsk
G. Chernysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Россия, Tomsk
V. Smol’yakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Россия, Tomsk
P. Shchetinin
National Research Tomsk State University
Email: plot160@mail.ru
Россия, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: plot160@mail.ru
Россия, Syktyvkar, Komi Republic
I. Chukicheva
National Research Tomsk State University
Email: plot160@mail.ru
Россия, Tomsk
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Россия, Tomsk
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