Cardioprotective Activity of 2,6-Diisobornyl-4-Methylphenol in Acute Myocardial Ischemia/Reperfusion in Rats
- Авторлар: Plotnikova T.1, Chernysheva G.2, Smol’yakova V.2, Shchetinin P.3, Kuchin A.4, Chukicheva I.3, Plotnikov M.2
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Мекемелер:
- Siberian State Medical University, Ministry of Health of Russia
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- National Research Tomsk State University
- Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Шығарылым: Том 165, № 5 (2018)
- Беттер: 657-659
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240638
- DOI: https://doi.org/10.1007/s10517-018-4235-2
- ID: 240638
Дәйексөз келтіру
Аннотация
We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group.
Авторлар туралы
T. Plotnikova
Siberian State Medical University, Ministry of Health of Russia
Хат алмасуға жауапты Автор.
Email: plot160@mail.ru
Ресей, Tomsk
G. Chernysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Ресей, Tomsk
V. Smol’yakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Ресей, Tomsk
P. Shchetinin
National Research Tomsk State University
Email: plot160@mail.ru
Ресей, Tomsk
A. Kuchin
Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: plot160@mail.ru
Ресей, Syktyvkar, Komi Republic
I. Chukicheva
National Research Tomsk State University
Email: plot160@mail.ru
Ресей, Tomsk
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plot160@mail.ru
Ресей, Tomsk
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