Individual Differences of Multipotent Mesenchymal Stromal Cells Manifesting in during Interaction with Lymphocytes
- 作者: Kapranov N.1, Davydova Y.1, Gal’tseva I.1, Petinati N.1, Sats N.1, Drize N.1, Kuz’mina L.1, Parovichnikova E.1, Savchenko V.1
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隶属关系:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- 期: 卷 165, 编号 4 (2018)
- 页面: 584-588
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240574
- DOI: https://doi.org/10.1007/s10517-018-4218-3
- ID: 240574
如何引用文章
详细
Analysis of changes in lymphocyte subpopulations during co-culturing with multipotent mesenchymal stromal cells (MSC) revealed two distinct MSC groups: one group (A) increased HLA-DR expression on lymphocytes during co-culturing and the other (B) did not change it in comparison with lymphocyte monoculture. In stromal cells interacting with lymphocytes, expression of HLA-DR molecules was initiated, but only in samples that induced enhanced expression on lymphocytes and irrespectively of whether allogeneic or autologous lymphocytes were used for co-culturing with MSC. In group A, the relative expression of IDO1 significantly increased in comparison with group B. The revealed individual differences in MSC can explain why not all MSC samples are effective in the treatment of autoimmune diseases, acute “graft—versus—host” disease, and other pathologies.
作者简介
N. Kapranov
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
Yu. Davydova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
I. Gal’tseva
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
N. Petinati
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
N. Sats
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
N. Drize
National Research Center for Hematology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
L. Kuz’mina
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
E. Parovichnikova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
V. Savchenko
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
俄罗斯联邦, Moscow
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