Individual Differences of Multipotent Mesenchymal Stromal Cells Manifesting in during Interaction with Lymphocytes
- Авторлар: Kapranov N.1, Davydova Y.1, Gal’tseva I.1, Petinati N.1, Sats N.1, Drize N.1, Kuz’mina L.1, Parovichnikova E.1, Savchenko V.1
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Мекемелер:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 4 (2018)
- Беттер: 584-588
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240574
- DOI: https://doi.org/10.1007/s10517-018-4218-3
- ID: 240574
Дәйексөз келтіру
Аннотация
Analysis of changes in lymphocyte subpopulations during co-culturing with multipotent mesenchymal stromal cells (MSC) revealed two distinct MSC groups: one group (A) increased HLA-DR expression on lymphocytes during co-culturing and the other (B) did not change it in comparison with lymphocyte monoculture. In stromal cells interacting with lymphocytes, expression of HLA-DR molecules was initiated, but only in samples that induced enhanced expression on lymphocytes and irrespectively of whether allogeneic or autologous lymphocytes were used for co-culturing with MSC. In group A, the relative expression of IDO1 significantly increased in comparison with group B. The revealed individual differences in MSC can explain why not all MSC samples are effective in the treatment of autoimmune diseases, acute “graft—versus—host” disease, and other pathologies.
Авторлар туралы
N. Kapranov
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
Yu. Davydova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
I. Gal’tseva
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
N. Petinati
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
N. Sats
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
N. Drize
National Research Center for Hematology, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: ndrize@yandex.ru
Ресей, Moscow
L. Kuz’mina
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
E. Parovichnikova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
V. Savchenko
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Ресей, Moscow
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