Individual Differences of Multipotent Mesenchymal Stromal Cells Manifesting in during Interaction with Lymphocytes
- Authors: Kapranov N.M.1, Davydova Y.O.1, Gal’tseva I.V.1, Petinati N.A.1, Sats N.V.1, Drize N.I.1, Kuz’mina L.A1, Parovichnikova E.N.1, Savchenko V.G.1
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Affiliations:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 4 (2018)
- Pages: 584-588
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240574
- DOI: https://doi.org/10.1007/s10517-018-4218-3
- ID: 240574
Cite item
Abstract
Analysis of changes in lymphocyte subpopulations during co-culturing with multipotent mesenchymal stromal cells (MSC) revealed two distinct MSC groups: one group (A) increased HLA-DR expression on lymphocytes during co-culturing and the other (B) did not change it in comparison with lymphocyte monoculture. In stromal cells interacting with lymphocytes, expression of HLA-DR molecules was initiated, but only in samples that induced enhanced expression on lymphocytes and irrespectively of whether allogeneic or autologous lymphocytes were used for co-culturing with MSC. In group A, the relative expression of IDO1 significantly increased in comparison with group B. The revealed individual differences in MSC can explain why not all MSC samples are effective in the treatment of autoimmune diseases, acute “graft—versus—host” disease, and other pathologies.
About the authors
N. M. Kapranov
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
Yu. O. Davydova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
I. V. Gal’tseva
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
N. A. Petinati
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
N. V. Sats
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
N. I. Drize
National Research Center for Hematology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: ndrize@yandex.ru
Russian Federation, Moscow
L. A Kuz’mina
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
E. N. Parovichnikova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
V. G. Savchenko
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: ndrize@yandex.ru
Russian Federation, Moscow
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