Effects of Glycolipid Rhodococcus Biosurfactant on Innate and Adaptive Immunity Parameters In Vivo
- 作者: Gein S.1,2, Kochina O.1, Kuyukina M.1,2, Ivshina I.1,2
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Perm State National Research University
- 期: 卷 165, 编号 3 (2018)
- 页面: 368-372
- 栏目: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240313
- DOI: https://doi.org/10.1007/s10517-018-4172-0
- ID: 240313
如何引用文章
详细
The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected in vivo, do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.
作者简介
S. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
编辑信件的主要联系方式.
Email: gein@iegm.ru
俄罗斯联邦, Perm; Perm
O. Kochina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: gein@iegm.ru
俄罗斯联邦, Perm
M. Kuyukina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
俄罗斯联邦, Perm; Perm
I. Ivshina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
俄罗斯联邦, Perm; Perm
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