Enviar artigo por via de e-mail Effects of Glycolipid Rhodococcus Biosurfactant on Innate and Adaptive Immunity Parameters In Vivo
- Autores: Gein S.1,2, Kochina O.1, Kuyukina M.1,2, Ivshina I.1,2
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Perm State National Research University
- Edição: Volume 165, Nº 3 (2018)
- Páginas: 368-372
- Seção: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240313
- DOI: https://doi.org/10.1007/s10517-018-4172-0
- ID: 240313
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Resumo
The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected in vivo, do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.
Sobre autores
S. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Autor responsável pela correspondência
Email: gein@iegm.ru
Rússia, Perm; Perm
O. Kochina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: gein@iegm.ru
Rússia, Perm
M. Kuyukina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
Rússia, Perm; Perm
I. Ivshina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
Rússia, Perm; Perm
