Email this article Effects of Glycolipid Rhodococcus Biosurfactant on Innate and Adaptive Immunity Parameters In Vivo
- Authors: Gein S.V.1,2, Kochina O.A.1, Kuyukina M.S.1,2, Ivshina I.B.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Perm State National Research University
- Issue: Vol 165, No 3 (2018)
- Pages: 368-372
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240313
- DOI: https://doi.org/10.1007/s10517-018-4172-0
- ID: 240313
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Abstract
The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected in vivo, do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.
About the authors
S. V. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Author for correspondence.
Email: gein@iegm.ru
Russian Federation, Perm; Perm
O. A. Kochina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: gein@iegm.ru
Russian Federation, Perm
M. S. Kuyukina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
Russian Federation, Perm; Perm
I. B. Ivshina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Perm State National Research University
Email: gein@iegm.ru
Russian Federation, Perm; Perm
