Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor
- 作者: Sevostyanova V.1, Antonova L.1, Velikanova E.1, Matveeva V.1, Krivkina E.1, Glushkova T.1, Mironov A.1, Burago A.1, Barbarash L.1
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隶属关系:
- Research Institute for Complex Problems of Cardiovascular Disease
- 期: 卷 165, 编号 2 (2018)
- 页面: 264-268
- 栏目: Biotechnology
- URL: https://journals.rcsi.science/0007-4888/article/view/240216
- DOI: https://doi.org/10.1007/s10517-018-4144-4
- ID: 240216
如何引用文章
详细
We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.
作者简介
V. Sevostyanova
Research Institute for Complex Problems of Cardiovascular Disease
编辑信件的主要联系方式.
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
L. Antonova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
E. Velikanova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
V. Matveeva
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
E. Krivkina
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
T. Glushkova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
A. Mironov
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
A. Burago
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo
L. Barbarash
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
俄罗斯联邦, Kemerovo