Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor
- Authors: Sevostyanova V.V.1, Antonova L.V.1, Velikanova E.A.1, Matveeva V.G.1, Krivkina E.O.1, Glushkova T.V.1, Mironov A.V.1, Burago A.Y.1, Barbarash L.S.1
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Affiliations:
- Research Institute for Complex Problems of Cardiovascular Disease
- Issue: Vol 165, No 2 (2018)
- Pages: 264-268
- Section: Biotechnology
- URL: https://journals.rcsi.science/0007-4888/article/view/240216
- DOI: https://doi.org/10.1007/s10517-018-4144-4
- ID: 240216
Cite item
Abstract
We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.
About the authors
V. V. Sevostyanova
Research Institute for Complex Problems of Cardiovascular Disease
Author for correspondence.
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
L. V. Antonova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
E. A. Velikanova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
V. G. Matveeva
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
E. O. Krivkina
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
T. V. Glushkova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
A. V. Mironov
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
A. Yu. Burago
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo
L. S. Barbarash
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Russian Federation, Kemerovo