Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor
- Авторы: Sevostyanova V.1, Antonova L.1, Velikanova E.1, Matveeva V.1, Krivkina E.1, Glushkova T.1, Mironov A.1, Burago A.1, Barbarash L.1
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Учреждения:
- Research Institute for Complex Problems of Cardiovascular Disease
- Выпуск: Том 165, № 2 (2018)
- Страницы: 264-268
- Раздел: Biotechnology
- URL: https://journals.rcsi.science/0007-4888/article/view/240216
- DOI: https://doi.org/10.1007/s10517-018-4144-4
- ID: 240216
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Аннотация
We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.
Об авторах
V. Sevostyanova
Research Institute for Complex Problems of Cardiovascular Disease
Автор, ответственный за переписку.
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
L. Antonova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
E. Velikanova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
V. Matveeva
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
E. Krivkina
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
T. Glushkova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
A. Mironov
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
A. Burago
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo
L. Barbarash
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Россия, Kemerovo