Endothelialization of Polycaprolactone Vascular Graft under the Action of Locally Applied Vascular Endothelial Growth Factor
- Авторлар: Sevostyanova V.1, Antonova L.1, Velikanova E.1, Matveeva V.1, Krivkina E.1, Glushkova T.1, Mironov A.1, Burago A.1, Barbarash L.1
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Мекемелер:
- Research Institute for Complex Problems of Cardiovascular Disease
- Шығарылым: Том 165, № 2 (2018)
- Беттер: 264-268
- Бөлім: Biotechnology
- URL: https://journals.rcsi.science/0007-4888/article/view/240216
- DOI: https://doi.org/10.1007/s10517-018-4144-4
- ID: 240216
Дәйексөз келтіру
Аннотация
We have previously developed a polycaprolactone (PCL) vascular graft with incorporated vascular endothelial growth factor (VEGF). Functioning of the PCL/VEGF graft in rat circulatory system over 1, 3 and 6 months after implantation into abdominal aorta was tested. Graft patency and formation of vascular wall elements were assessed histologically and by immunofluorescence staining for von Willebrand factor, CD31, CD34, and collagens I and IV and DAPI staining. Local application of VEGF promoted endothelialization and improved patency of the graft. The wall of the PCL/VEGF graft underwent remodeling due to active cellular infiltration and the extracellular matrix deposition.
Авторлар туралы
V. Sevostyanova
Research Institute for Complex Problems of Cardiovascular Disease
Хат алмасуға жауапты Автор.
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
L. Antonova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
E. Velikanova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
V. Matveeva
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
E. Krivkina
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
T. Glushkova
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
A. Mironov
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
A. Burago
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo
L. Barbarash
Research Institute for Complex Problems of Cardiovascular Disease
Email: sevostyanova.victoria@gmail.com
Ресей, Kemerovo