NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood
- 作者: Kuzmina U.1, Zainullina L.1, Sadovnikov S.1, Vakhitov V.1, Vakhitova Y.1
-
隶属关系:
- Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
- 期: 卷 165, 编号 2 (2018)
- 页面: 252-255
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240208
- DOI: https://doi.org/10.1007/s10517-018-4141-7
- ID: 240208
如何引用文章
详细
To determine the role of NMDA receptors in the functional regulation of immunocompetent cells, comparative assay was carried out for genes expressed in the mononuclears in peripheral blood of healthy persons under normal conditions and after blockade of these receptors. The genes, whose expression changed in response to blockade of NMDA receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (IL4, VCAM1, and CDKN2A), apoptosis (BAX, MYC, CDKN2A, HSPB1, and CADD45A), activation (IL4R, IL4, VCAM1, and CDKN2A), and differentiation (IL4, VCAM1, and BAX).
作者简介
U. Kuzmina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
俄罗斯联邦, Ufa
L. Zainullina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
俄罗斯联邦, Ufa
S. Sadovnikov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
俄罗斯联邦, Ufa
V. Vakhitov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
俄罗斯联邦, Ufa
Yu. Vakhitova
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: juvv73@gmail.com
俄罗斯联邦, Ufa