NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood
- Authors: Kuzmina U.S.1, Zainullina L.F.1, Sadovnikov S.V.1, Vakhitov V.A.1, Vakhitova Y.V.1
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Affiliations:
- Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
- Issue: Vol 165, No 2 (2018)
- Pages: 252-255
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240208
- DOI: https://doi.org/10.1007/s10517-018-4141-7
- ID: 240208
Cite item
Abstract
To determine the role of NMDA receptors in the functional regulation of immunocompetent cells, comparative assay was carried out for genes expressed in the mononuclears in peripheral blood of healthy persons under normal conditions and after blockade of these receptors. The genes, whose expression changed in response to blockade of NMDA receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (IL4, VCAM1, and CDKN2A), apoptosis (BAX, MYC, CDKN2A, HSPB1, and CADD45A), activation (IL4R, IL4, VCAM1, and CDKN2A), and differentiation (IL4, VCAM1, and BAX).
About the authors
U. Sh. Kuzmina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Russian Federation, Ufa
L. F. Zainullina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Russian Federation, Ufa
S. V. Sadovnikov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Russian Federation, Ufa
V. A. Vakhitov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Russian Federation, Ufa
Yu. V. Vakhitova
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Author for correspondence.
Email: juvv73@gmail.com
Russian Federation, Ufa