NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood
- Autores: Kuzmina U.1, Zainullina L.1, Sadovnikov S.1, Vakhitov V.1, Vakhitova Y.1
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Afiliações:
- Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
- Edição: Volume 165, Nº 2 (2018)
- Páginas: 252-255
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240208
- DOI: https://doi.org/10.1007/s10517-018-4141-7
- ID: 240208
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Resumo
To determine the role of NMDA receptors in the functional regulation of immunocompetent cells, comparative assay was carried out for genes expressed in the mononuclears in peripheral blood of healthy persons under normal conditions and after blockade of these receptors. The genes, whose expression changed in response to blockade of NMDA receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (IL4, VCAM1, and CDKN2A), apoptosis (BAX, MYC, CDKN2A, HSPB1, and CADD45A), activation (IL4R, IL4, VCAM1, and CDKN2A), and differentiation (IL4, VCAM1, and BAX).
Sobre autores
U. Kuzmina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Rússia, Ufa
L. Zainullina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Rússia, Ufa
S. Sadovnikov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Rússia, Ufa
V. Vakhitov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Rússia, Ufa
Yu. Vakhitova
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: juvv73@gmail.com
Rússia, Ufa