Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo
- 作者: Kurskaya O.1, Murashkina T.1, Alekseev A.1, Sharshov K.1, Romakh L.1, Derko A.1, Troitskii A.1, Bystrova T.1, Shkurupy V.1,2, Shestopalov A.1
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隶属关系:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk Medical University, Ministry of Health of the Russian Federation
- 期: 卷 165, 编号 2 (2018)
- 页面: 248-251
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240200
- DOI: https://doi.org/10.1007/s10517-018-4140-8
- ID: 240200
如何引用文章
详细
Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
作者简介
O. Kurskaya
Research Institute of Experimental and Clinical Medicine
编辑信件的主要联系方式.
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
T. Murashkina
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
A. Alekseev
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
K. Sharshov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
L. Romakh
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
A. Derko
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
T. Bystrova
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk
V. Shkurupy
Research Institute of Experimental and Clinical Medicine; Novosibirsk Medical University, Ministry of Health of the Russian Federation
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
俄罗斯联邦, Novosibirsk