Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo
- Авторлар: Kurskaya O.1, Murashkina T.1, Alekseev A.1, Sharshov K.1, Romakh L.1, Derko A.1, Troitskii A.1, Bystrova T.1, Shkurupy V.1,2, Shestopalov A.1
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Мекемелер:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 2 (2018)
- Беттер: 248-251
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240200
- DOI: https://doi.org/10.1007/s10517-018-4140-8
- ID: 240200
Дәйексөз келтіру
Аннотация
Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
Авторлар туралы
O. Kurskaya
Research Institute of Experimental and Clinical Medicine
Хат алмасуға жауапты Автор.
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
T. Murashkina
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
A. Alekseev
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
K. Sharshov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
L. Romakh
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
A. Derko
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
T. Bystrova
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk
V. Shkurupy
Research Institute of Experimental and Clinical Medicine; Novosibirsk Medical University, Ministry of Health of the Russian Federation
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk; Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Ресей, Novosibirsk