Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo
- Authors: Kurskaya O.G.1, Murashkina T.A.1, Alekseev A.Y.1, Sharshov K.A.1, Romakh L.P.1, Derko A.A.1, Troitskii A.V.1, Bystrova T.N.1, Shkurupy V.A.1,2, Shestopalov A.M.1
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Affiliations:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 2 (2018)
- Pages: 248-251
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240200
- DOI: https://doi.org/10.1007/s10517-018-4140-8
- ID: 240200
Cite item
Abstract
Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
About the authors
O. G. Kurskaya
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
T. A. Murashkina
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
A. Yu. Alekseev
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
K. A. Sharshov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
L. P. Romakh
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
A. A. Derko
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
A. V. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
T. N. Bystrova
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk
V. A. Shkurupy
Research Institute of Experimental and Clinical Medicine; Novosibirsk Medical University, Ministry of Health of the Russian Federation
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
A. M. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Russian Federation, Novosibirsk