Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia
- 作者: Apanasevich V.1, Plekhova N.1, Lagureva A.1, Goncharov A.1, Kotsyurbii E.1, Plotnikova O.1, Sivoraksha D.1, Tarakova O.2, Molchanova V.3, Luk’yanov P.3
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隶属关系:
- Pacific State Medical University, Ministry of Health of the Russian Federation
- Far-Eastern Federal University, Ministry of Education and Science of the Russian Federation
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
- 期: 卷 165, 编号 1 (2018)
- 页面: 40-43
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/239959
- DOI: https://doi.org/10.1007/s10517-018-4094-x
- ID: 239959
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详细
The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.
作者简介
V. Apanasevich
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
N. Plekhova
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
A. Lagureva
Pacific State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
A. Goncharov
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
E. Kotsyurbii
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
O. Plotnikova
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
D. Sivoraksha
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
O. Tarakova
Far-Eastern Federal University, Ministry of Education and Science of the Russian Federation
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
V. Molchanova
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok
P. Luk’yanov
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
Email: sandy767@mail.ru
俄罗斯联邦, Vladivostok