Email this article Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia
- Authors: Apanasevich V.I.1, Plekhova N.G.1, Lagureva A.V.1, Goncharov A.V.1, Kotsyurbii E.A.1, Plotnikova O.S.1, Sivoraksha D.A.1, Tarakova O.V.2, Molchanova V.I.3, Luk’yanov P.A.3
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Affiliations:
- Pacific State Medical University, Ministry of Health of the Russian Federation
- Far-Eastern Federal University, Ministry of Education and Science of the Russian Federation
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
- Issue: Vol 165, No 1 (2018)
- Pages: 40-43
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/239959
- DOI: https://doi.org/10.1007/s10517-018-4094-x
- ID: 239959
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Abstract
The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.
About the authors
V. I. Apanasevich
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
N. G. Plekhova
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
A. V. Lagureva
Pacific State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: sandy767@mail.ru
Russian Federation, Vladivostok
A. V. Goncharov
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
E. A. Kotsyurbii
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
O. S. Plotnikova
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
D. A. Sivoraksha
Pacific State Medical University, Ministry of Health of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
O. V. Tarakova
Far-Eastern Federal University, Ministry of Education and Science of the Russian Federation
Email: sandy767@mail.ru
Russian Federation, Vladivostok
V. I. Molchanova
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
Email: sandy767@mail.ru
Russian Federation, Vladivostok
P. A. Luk’yanov
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science
Email: sandy767@mail.ru
Russian Federation, Vladivostok
