In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing
- 作者: Nikulin S.1,2, Raigorodskaya M.1, Poloznikov A.1, Zakharova G.1, Schumacher U.3, Wicklein D.3, Stürken C.3, Riecken K.3, Fomicheva K.4, Alekseev B.4, Shkurnikov M.4
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隶属关系:
- BioClinicum Center
- Moscow Institute of Physics and Technology (MIPT)
- University Medical Center Hamburg-Eppendorf
- P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 5 (2018)
- 页面: 688-692
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239856
- DOI: https://doi.org/10.1007/s10517-018-4060-7
- ID: 239856
如何引用文章
详细
IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer.
作者简介
S. Nikulin
BioClinicum Center; Moscow Institute of Physics and Technology (MIPT)
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow; Moscow
M. Raigorodskaya
BioClinicum Center
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow
A. Poloznikov
BioClinicum Center
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow
G. Zakharova
BioClinicum Center
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
德国, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
德国, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
德国, Hamburg
K. Riecken
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
德国, Hamburg
K. Fomicheva
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow
B. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow
M. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: mshkurnikov@gmail.com
俄罗斯联邦, Moscow