Enviar artigo por via de e-mail In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing
- Autores: Nikulin S.1,2, Raigorodskaya M.1, Poloznikov A.1, Zakharova G.1, Schumacher U.3, Wicklein D.3, Stürken C.3, Riecken K.3, Fomicheva K.4, Alekseev B.4, Shkurnikov M.4
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Afiliações:
- BioClinicum Center
- Moscow Institute of Physics and Technology (MIPT)
- University Medical Center Hamburg-Eppendorf
- P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
- Edição: Volume 164, Nº 5 (2018)
- Páginas: 688-692
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239856
- DOI: https://doi.org/10.1007/s10517-018-4060-7
- ID: 239856
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Resumo
IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer.
Sobre autores
S. Nikulin
BioClinicum Center; Moscow Institute of Physics and Technology (MIPT)
Email: mshkurnikov@gmail.com
Rússia, Moscow; Moscow
M. Raigorodskaya
BioClinicum Center
Email: mshkurnikov@gmail.com
Rússia, Moscow
A. Poloznikov
BioClinicum Center
Email: mshkurnikov@gmail.com
Rússia, Moscow
G. Zakharova
BioClinicum Center
Email: mshkurnikov@gmail.com
Rússia, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
Alemanha, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
Alemanha, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
Alemanha, Hamburg
K. Riecken
University Medical Center Hamburg-Eppendorf
Email: mshkurnikov@gmail.com
Alemanha, Hamburg
K. Fomicheva
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow
B. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow
M. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: mshkurnikov@gmail.com
Rússia, Moscow
