Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites
- 作者: Sinyakova N.1, Kulikova E.1, Englevskii N.1, Kulikov A.1
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隶属关系:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 164, 编号 5 (2018)
- 页面: 620-623
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239790
- DOI: https://doi.org/10.1007/s10517-018-4045-6
- ID: 239790
如何引用文章
详细
We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the “novel tank” test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.
作者简介
N. Sinyakova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: sinyakova1985@gmail.com
俄罗斯联邦, Novosibirsk
E. Kulikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
俄罗斯联邦, Novosibirsk
N. Englevskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
俄罗斯联邦, Novosibirsk
A. Kulikov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
俄罗斯联邦, Novosibirsk