Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites
- Авторлар: Sinyakova N.1, Kulikova E.1, Englevskii N.1, Kulikov A.1
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Мекемелер:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Шығарылым: Том 164, № 5 (2018)
- Беттер: 620-623
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239790
- DOI: https://doi.org/10.1007/s10517-018-4045-6
- ID: 239790
Дәйексөз келтіру
Аннотация
We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the “novel tank” test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.
Авторлар туралы
N. Sinyakova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: sinyakova1985@gmail.com
Ресей, Novosibirsk
E. Kulikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Ресей, Novosibirsk
N. Englevskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Ресей, Novosibirsk
A. Kulikov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Ресей, Novosibirsk