Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites
- Авторы: Sinyakova N.1, Kulikova E.1, Englevskii N.1, Kulikov A.1
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Учреждения:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Выпуск: Том 164, № 5 (2018)
- Страницы: 620-623
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239790
- DOI: https://doi.org/10.1007/s10517-018-4045-6
- ID: 239790
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Аннотация
We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the “novel tank” test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.
Об авторах
N. Sinyakova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: sinyakova1985@gmail.com
Россия, Novosibirsk
E. Kulikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Россия, Novosibirsk
N. Englevskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Россия, Novosibirsk
A. Kulikov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sinyakova1985@gmail.com
Россия, Novosibirsk