The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
- 作者: Lukyanova L.1, Kirova Y.1, Germanova E.1
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隶属关系:
- Research Institute of General Pathology and Pathophysiology
- 期: 卷 164, 编号 3 (2018)
- 页面: 298-303
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239564
- DOI: https://doi.org/10.1007/s10517-018-3976-2
- ID: 239564
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详细
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
作者简介
L. Lukyanova
Research Institute of General Pathology and Pathophysiology
编辑信件的主要联系方式.
Email: ldlukyanova@gmail.com
俄罗斯联邦, Moscow
Yu. Kirova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
俄罗斯联邦, Moscow
E. Germanova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
俄罗斯联邦, Moscow