The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
- Authors: Lukyanova L.D.1, Kirova Y.I.1, Germanova E.L.1
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Affiliations:
- Research Institute of General Pathology and Pathophysiology
- Issue: Vol 164, No 3 (2018)
- Pages: 298-303
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239564
- DOI: https://doi.org/10.1007/s10517-018-3976-2
- ID: 239564
Cite item
Abstract
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
About the authors
L. D. Lukyanova
Research Institute of General Pathology and Pathophysiology
Author for correspondence.
Email: ldlukyanova@gmail.com
Russian Federation, Moscow
Yu. I. Kirova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Russian Federation, Moscow
E. L. Germanova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Russian Federation, Moscow