The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
- Авторлар: Lukyanova L.1, Kirova Y.1, Germanova E.1
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Мекемелер:
- Research Institute of General Pathology and Pathophysiology
- Шығарылым: Том 164, № 3 (2018)
- Беттер: 298-303
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239564
- DOI: https://doi.org/10.1007/s10517-018-3976-2
- ID: 239564
Дәйексөз келтіру
Аннотация
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
Авторлар туралы
L. Lukyanova
Research Institute of General Pathology and Pathophysiology
Хат алмасуға жауапты Автор.
Email: ldlukyanova@gmail.com
Ресей, Moscow
Yu. Kirova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Ресей, Moscow
E. Germanova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Ресей, Moscow