The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
- Авторы: Lukyanova L.1, Kirova Y.1, Germanova E.1
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Учреждения:
- Research Institute of General Pathology and Pathophysiology
- Выпуск: Том 164, № 3 (2018)
- Страницы: 298-303
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239564
- DOI: https://doi.org/10.1007/s10517-018-3976-2
- ID: 239564
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Аннотация
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
Об авторах
L. Lukyanova
Research Institute of General Pathology and Pathophysiology
Автор, ответственный за переписку.
Email: ldlukyanova@gmail.com
Россия, Moscow
Yu. Kirova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Россия, Moscow
E. Germanova
Research Institute of General Pathology and Pathophysiology
Email: ldlukyanova@gmail.com
Россия, Moscow